SPINA BIFIDA AND HYDROCEPHALUS
ASSOCIATION OF CANADA
RESEARCH GRANTS AWARDED 1987-2005

2005

· Risk of Neural Tube Defects in Association with Elevated C-Reactive Protein - Dr. J. Ray

2004

· Maternal Diabetes Mellitus and the Risk of Neural Tube Defects;
· Maternal Ethnicity and the Risk of Neural Tube Defects

2002-2005

· "Developmental Issues Related to Cerebrospinal Fluid Transport and the Importance of the Extracranial Lymphatic System" This award has been granted for 3 years. This award is offered in partnership with SBHAC based on a 1:1 funding ratio with the Canadian Institutes of Health Research (CIHR).

2001

· Eye Movement Abnormalities and Cerebellar Dysmorphology in Children with Spina Bifida and Hydrocephalus

2000

· A Mechanical Investigation into the causes of Spina Bifida
· The Effects of Physical Activity and Bisphosphonate Supplementation on the Prevention and Reduction of “Secondary” Handicaps in Children with Spina Bifida

1999

· Developmental changes in CSF clearance mechanisms; relevance to pediatric hydrocephalus.
· “Self-Esteem and Social Support: Strengthening the Social Relationships of Young People with Spina Bifida”

1998

· No grants awarded

1997

· Identification of the Primary Lesion of the Spina Bifida and attempt to induce axonal growth using Polymer Matrix.
· Neural Tube Defects and Homocysteine Metabolism.

1996

· Renal Risk Project.
· Mesenchymal-Epithelial Transformation in Secondary Neurulation.
· Surgical Correction of Congenital Kyphosis and the Effects of Cordotomy on Bowel and Bladder Function in Myelomingocele.
· Toward Improved Diagnosis of Visual Learning Problems in Children with Hydrocephalus.

1995

· Mesenchymal-Epithelial Transformation in Secondary Neurulation.
· Timing Functions of the Cerebellum: Their Role in Motor & Language Skills with Children with Hydrocephalus.
· The Ventriculoperitoneal Shunt Design Trial.
· Sleep Disordered Breathing in Children with Myelomeningocele.

1994

· Expression Analysis of Vertebrate E (spl) Gene Homologues.
· Neural Tube Defects in the B.C. Sikh Population.
· Sleep Disordered Breathing in Children with Myelomeningocele.
· Conversational Patterns in Children with Myelomeningocele & Hydrocephalus.
· Development of the Father-Infant Relationship with an Infant who has Spina Bifida.

1993

· Does Amniotic Fluid Damage the Fetal Spinal Cord?
· Molecular Genetic Basis for Spina Bifida.
· Measuring Functional Outcome of Spine Surgery in Children with Spina Bifida.

1992

· Morbidity and Mortality in Hydrocephalic Children Associated with Cerebrospinal Fluid Shunt Valves: Slit & Core or Ball & Spring.
· Differentiation Waves During Formation of the Nervous System.
· Assessment of Methods for Rapid Diagnosis of Urinary Tract Infections in Children with Meningomyelocele.
· Molecular Genetics Basis for Spina Bifida.
· Support and Burden of Mothers of Children with Spina Bifida.

1991

· Comparison of Normal and Abnormal Neural Tube Closure.
· Mechanical Properties of Developing Neural Plate
· Glucose Utilization in Neonatal Hydrocephalus.
· The Use of Stomach in Creating a Urinary Sphincter.

1990

· Mineral Analysis of Anencephalic Tissue and Control Tissue.
· The Effects of: (i) Experimentally Induced Hydrocephalus on the Cerebral Cortex and (ii) Vasopressin on Brain Water Content and Intracranial Pressure.
· Rotating Microscope for Observing Neurulation.
· Comparison of Bacterieurea in Subjects using Intermittent Catheterization: Sterile Catheters Versus Clean Reused Catheters.
· Gastric Muscularis as Physiological Urinary Sphincter.

1989

· The Effects of: (I) Experimentally induced Hydrocephalus on the Cerebral Cortex and (ii) Vasopressin on Brain Water Content and Intracranial Pressure. (2nd year of 3 year project)
· Early Brain Development. (3rd year)
· Chronic in vivo Evaluation of CSF Shunt Function in a Hydrophalic Model.
· Investigation of the Symplahtetic Nervous System in Myelodysplasia and its Relation to Vesico-Urethral Dysfunction.
· Identification of Genes Selectively Expressed in the Neuroectoderm of Amphibians During Neurulation.

1988

· The Effects of: (I) Experimentally induced Hydrocephalus on the Cerebral Cortex and (ii) Vasopressin on Brain Water Content and Intracranial Pressure. (1st year of 3 year project)
· Development of the Neural Tube. (2nd year)
· Study of the Surgical Release of Tethered Cords.
· Myelomeningocele Clinic Data Collection.

1987

· Mechanics of Early Neurulation. (1st year)
· To Assess the Long Term Neurological, Orthopaedic and Urological Consequences of the Surgical Release of Tethered Cords in Myelomeningocele Children.